APOL1 Risk Variants Independently Associated With Early Cardiovascular Disease Death
نویسندگان
چکیده
منابع مشابه
APOL1 Risk Variants Independently Associated With Early Cardiovascular Disease Death
Introduction The relationship of APOL1 renal risk variants to cardiovascular disease (CVD) is controversial and was the subject of this investigation. Methods Age, cause of death, and nephrosclerosis (the latter defined by glomerulosclerosis) were analyzed in the autopsies of 162 African Americans and 136 whites genotyped for APOL1 risk alleles. Results Sudden deaths represented >75% of CVD...
متن کاملEffect of APOL1 disease risk variants on APOL1 gene product
Gene sequence mutations may alter mRNA transcription, transcript stability, protein translation, protein stability and protein folding. Apolipoprotein L1 (APOL1) has two sets of sequence variants that are risk factors for kidney disease development, APOL1G1 (substitution mutation) and APOL1G2 (deletion mutation). Our present study focuses on the impact of these variants on APOL1 mRNA transcript...
متن کاملAPOL1 and Cardiovascular Disease
Observational studies have long established that African Americans have a higher risk for developing chronic kidney disease (CKD) with faster progression to end-stage renal disease compared with Americans not of African descent, independent of socioeconomic and traditional clinical risk factors. But it was not until 2010 that the genetic basis behind this association became more apparent when 2...
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INTRODUCTION Relationships between apolipoprotein L1 gene (APOL1) renal-risk variants (RRVs) and cardiovascular disease (CVD) remain controversial. To clarify associations between APOL1 and CVD, 2,568 African American Systolic Blood Pressure Intervention Trial (SPRINT) participants were assessed for the incidence of CVD events (primary composite including non-fatal myocardial infarction, acute ...
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Patients with chronic kidney disease (CKD) suffer from a high burden of cardiovascular disease (CVD) [1]. This is partly due to progressive deterioration of calciumephosphate homeostasis. Although the molecular mechanism of action of Klotho is not well understood, fibroblast growth factor-23 (FGF-23) and its coreceptor Klotho have emerged as pivotal players in calciumephosphate homeostasis. Klo...
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ژورنال
عنوان ژورنال: Kidney International Reports
سال: 2018
ISSN: 2468-0249
DOI: 10.1016/j.ekir.2017.08.007